Copper ion homeostasis

Across TCGA cell cohorts, RNA activity of the Copper ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCO1, PDCD5, and HINT1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion homeostasis activity versus SCO1 in LARGE_INTESTINE (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SCO1 →	+0.968	+0.179	<.001	<.001	3	11
STOMACH	PDCD5 →	-1.744	-0.280	.004	.001	3	10
LUNG_NSCLC_LUSC	HINT1 →	-3.160	-0.267	.005	.001	3	10
LUNG_NSCLC_LUSC	PGD →	-4.224	-0.247	.003	.006	3	9
LUNG_NSCLC_LUSC	EIF3G →	-1.059	-0.270	<.001	.001	3	8
LUNG_NSCLC_LUSC	TXN →	-2.532	-0.244	.003	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055070 vs SCO1 — LARGE_INTESTINE

Explore this scatter interactively →