Phosphate ion homeostasis

Across TCGA patient cohorts, RNA activity of the Phosphate ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSRP1, ALPL, and TSPAN9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphate ion homeostasis activity versus CSRP1 in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSRP1 →	+0.645	+0.086	<.001	<.001	3	7
LUAD	ALPL →	+0.802	+0.082	<.001	<.001	3	7
COAD	TSPAN9 →	+0.433	+0.052	<.001	.009	3	7
LSCC	EMILIN1 →	+0.631	+0.170	<.001	<.001	3	7
OV	SNX30 →	+0.368	+0.098	<.001	<.001	3	6
UCEC	RSU1 →	+0.425	+0.097	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055062 vs CSRP1 — UCEC

Explore this scatter interactively →