Phosphate ion homeostasis

Across TCGA patient cohorts, RNA activity of the Phosphate ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS2, HIF1A, and COL1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphate ion homeostasis activity versus ADAMTS2 in LSCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADAMTS2 →	+0.790	+0.405	.004	.001	3	6
BRCA	HIF1A →	+0.576	+0.226	.009	.004	3	5
GBM	COL1A1 →	+1.483	+0.148	<.001	<.001	3	5
LSCC	MXRA5 →	+1.019	+0.415	<.001	<.001	3	5
GBM	COL5A1 →	+1.065	+0.165	<.001	<.001	3	5
GBM	LOXL2 →	+0.852	+0.223	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055062 vs ADAMTS2 — LSCC

Explore this scatter interactively →