Phosphate ion homeostasis

Across TCGA cell cohorts, RNA activity of the Phosphate ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCD3, ZBTB18, and PYGB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLCD3 grouped by Phosphate ion homeostasis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLCD3 →	-1.172	-1.107	.001	<.001	3	4
LIVER	ZBTB18 →	-1.857	-1.311	<.001	.006	3	4
LIVER	PYGB →	-1.131	-1.182	<.001	.007	2	5
BONE	CDC42SE1 →	-0.869	-1.622	.002	<.001	3	4
BLOOD_Myeloma	CAPN5 →	-0.206	-1.580	.003	<.001	2	5
LUNG_NSCLC_LUAD	MTIF2 →	+0.479	+0.908	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLCD3 by Phosphate ion homeostasis activity — LARGE_INTESTINE

Explore this box plot interactively →