Phosphate ion homeostasis

Across TCGA cell cohorts, RNA activity of the Phosphate ion homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANAPC4, MYO7A, and FST, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANAPC4 grouped by Phosphate ion homeostasis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ANAPC4 →	-0.234	-0.606	.003	.006	3	4
CNS	MYO7A →	-0.192	-1.293	.001	.009	3	4
LUNG_NSCLC_LUAD	FST →	-0.195	-0.853	<.001	<.001	3	3
LARGE_INTESTINE	TLR3 →	-0.245	-1.466	.003	<.001	3	3
LARGE_INTESTINE	HNF1B →	+0.243	+0.878	.008	.007	3	3
OVARY	RNF185 →	+0.273	+0.806	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANAPC4 by Phosphate ion homeostasis activity — OVARY

Explore this box plot interactively →