Phosphate ion homeostasis

Across TCGA cell cohorts, RNA activity of the Phosphate ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM3, RPUSD3, and DDX60, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphate ion homeostasis activity versus MCM3 in LIVER (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MCM3 →	-1.261	-0.285	.001	<.001	3	4
LIVER	RPUSD3 →	-0.871	-0.285	<.001	<.001	3	4
LARGE_INTESTINE	DDX60 →	+2.919	+0.350	.006	.009	3	4
LARGE_INTESTINE	PTAFR →	+1.303	+0.439	<.001	.002	3	4
CNS	WDFY1 →	-0.634	-0.246	.005	.001	3	3
BONE	RBP4 →	+4.943	+0.413	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055062 vs MCM3 — LIVER

Explore this scatter interactively →