Asymmetric neuroblast division

Across TCGA cell cohorts, RNA activity of the Asymmetric neuroblast division pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB32, THTPA, and TM9SF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB32 grouped by Asymmetric neuroblast division-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RAB32 →	+2.135	+1.658	.001	.007	3	5
BREAST	THTPA →	-1.106	-1.099	<.001	<.001	3	5
BREAST	TM9SF1 →	-0.645	-0.789	<.001	.002	3	4
BREAST	CCDC183 →	-0.697	-0.802	.002	.001	3	4
LUNG_NSCLC_LUAD	TMEM199 →	-0.536	-0.785	.004	.003	3	4
SKIN	TMBIM4 →	-0.487	-1.244	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB32 by Asymmetric neuroblast division activity — LIVER

Explore this box plot interactively →