Asymmetric neuroblast division

Across TCGA cell cohorts, RNA activity of the Asymmetric neuroblast division pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF2, TNFSF9, and RAB24, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Asymmetric neuroblast division activity versus ARHGEF2 in BLOOD_Lymphoma (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARHGEF2 →	+1.721	+0.294	<.001	.004	3	6
STOMACH	TNFSF9 →	-2.864	-0.169	.005	.004	3	5
BLOOD_Lymphoma	RAB24 →	-1.314	-0.373	.002	<.001	3	5
BLOOD_Lymphoma	FBXO6 →	-2.010	-0.223	<.001	.001	3	5
BLOOD_Lymphoma	CRY1 →	-2.103	-0.223	<.001	.001	3	5
LARGE_INTESTINE	CXXC5 →	+1.966	+0.104	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055059 vs ARHGEF2 — BLOOD_Lymphoma

Explore this scatter interactively →