Neuroblast division

Across TCGA cell cohorts, RNA activity of the Neuroblast division pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STIM2, JAG1, and OTUD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STIM2 grouped by Neuroblast division-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	STIM2 →	-0.629	-0.753	.003	.009	3	4
LUNG_NSCLC_LUAD	JAG1 →	+1.402	+0.782	.005	.004	3	4
SKIN	OTUD3 →	+0.840	+1.068	<.001	<.001	3	4
BREAST	ZNF786 →	-0.613	-0.944	.007	<.001	3	4
BREAST	MRPS33 →	-0.600	-1.067	.001	<.001	3	4
PANCREAS	GOLPH3L →	-0.743	-1.122	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STIM2 by Neuroblast division activity — CNS

Explore this box plot interactively →