Neuroblast division

Across TCGA cell cohorts, RNA activity of the Neuroblast division pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAI, CRY1, and MAPK8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroblast division activity versus SCAI in BLOOD_Leukemia (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SCAI →	-0.712	-0.138	.002	.007	3	5
LARGE_INTESTINE	CRY1 →	-0.572	-0.090	.002	.001	2	6
BLOOD_Lymphoma	MAPK8 →	-1.335	-0.254	<.001	.002	3	4
LIVER	ORC3 →	-0.869	-0.219	.001	.006	3	4
LARGE_INTESTINE	MELK →	-0.889	-0.097	<.001	.001	3	4
BLOOD_Lymphoma	YES1 →	-1.769	-0.206	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055057 vs SCAI — BLOOD_Leukemia

Explore this scatter interactively →