Regulation of cardiac muscle tissue development

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle tissue development pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, PKN2, and PPP1R12A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Regulation of cardiac muscle tissue development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TEAD1 →	+0.312	+0.812	<.001	.006	3	4
BREAST	PKN2 →	+0.170	+1.012	.003	.002	3	4
CNS	PPP1R12A →	+0.443	+1.007	<.001	.001	3	4
CNS	AP3M2 →	+0.134	+0.764	.003	.005	3	4
SOFT_TISSUE	PRKCG →	+0.253	+1.738	<.001	<.001	3	4
SOFT_TISSUE	SIM2 →	+0.330	+1.180	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Regulation of cardiac muscle tissue development activity — LARGE_INTESTINE

Explore this box plot interactively →