Negative regulation of cardiac muscle tissue growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of cardiac muscle tissue growth pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL1A2, LAMA4, and AOC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle tissue growth activity versus COL1A2 in COAD (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COL1A2 →	+0.630	+0.032	.001	.005	2	6
BRCA	LAMA4 →	+0.378	+0.026	.004	.001	3	5
BRCA	AOC3 →	+0.722	+0.028	<.001	.001	3	5
LSCC	MOXD1 →	+0.570	+0.047	.001	<.001	3	4
BRCA	VIM →	+0.317	+0.026	<.001	<.001	3	4
COAD	C1orf198_S175 →	+0.234	+0.026	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055022 vs COL1A2 — COAD

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