Negative regulation of cardiac muscle tissue growth

Across TCGA patient cohorts, RNA activity of the Negative regulation of cardiac muscle tissue growth pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-1054P, GNG3, and NOP56P3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle tissue growth activity versus RNU6-1054P in OV (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RNU6-1054P →	-0.561	-0.195	<.001	<.001	3	3
UCEC	GNG3 →	-0.590	-0.186	<.001	.001	3	3
LSCC	NOP56P3 →	+0.685	+0.285	.004	.003	3	3
LSCC	OIP5 →	+0.658	+0.305	<.001	.001	3	2
COAD	EBF3 →	-0.236	-0.249	.002	.007	3	2
COAD	HAUS8 →	+0.321	+0.310	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055022 vs RNU6-1054P — OV

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