Negative regulation of cardiac muscle tissue growth

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle tissue growth pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIBAN2, FAM185A, and POC1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NIBAN2 grouped by Negative regulation of cardiac muscle tissue growth-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NIBAN2 →	-1.250	-0.322	.001	.003	3	4
LUNG_NSCLC_LUSC	FAM185A →	+1.093	+0.371	.003	.001	3	4
LIVER	POC1B →	+1.029	+0.391	.004	.001	3	3
UPPER_AERODIGESTIVE_TRACT	PHF7 →	+1.161	+0.395	<.001	.001	3	3
LARGE_INTESTINE	EHD4 →	-0.753	-0.234	.005	.006	3	3
LUNG_NSCLC_LUAD	SNRK →	+0.268	+0.418	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NIBAN2 by Negative regulation of cardiac muscle tissue growth activity — LARGE_INTESTINE

Explore this box plot interactively →