Negative regulation of cardiac muscle tissue growth

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle tissue growth pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS2, VGLL4, and ATP5F1A, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle tissue growth activity versus RGS2 in LIVER (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RGS2 →	+2.240	+0.181	<.001	.001	3	11
BLOOD_Lymphoma	VGLL4 →	+1.237	+0.077	.001	.007	3	10
PANCREAS	ATP5F1A →	+0.789	+0.132	<.001	<.001	3	7
BLOOD_Lymphoma	CTDP1 →	+1.166	+0.149	<.001	<.001	3	7
URINARY_TRACT	CST6 →	-4.595	-0.092	<.001	<.001	3	7
BREAST	CLIP4 →	-2.380	-0.112	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055022 vs RGS2 — LIVER

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