Ventricular cardiac muscle cell development

Across TCGA patient cohorts, RNA activity of the Ventricular cardiac muscle cell development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC25A20, TMSB10, and BZW2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle cell development activity versus SLC25A20 in GBM (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC25A20 →	-0.428	-0.079	<.001	<.001	3	5
LSCC	TMSB10 →	+0.336	+0.088	<.001	<.001	3	5
LUAD	BZW2 →	+0.393	+0.097	<.001	<.001	3	5
LUAD	CDK1 →	+0.641	+0.132	<.001	<.001	3	5
LUAD	DDX21_S121 →	+0.629	+0.094	<.001	<.001	3	5
UCEC	FHL2 →	+0.500	+0.081	.009	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055015 vs SLC25A20 — GBM

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