Ventricular cardiac muscle cell development

Across TCGA patient cohorts, RNA activity of the Ventricular cardiac muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LZTS1, ECM2, and SMOC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle cell development activity versus LZTS1 in GBM (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LZTS1 →	+0.907	+0.158	.001	.001	3	6
CCRCC	ECM2 →	+0.833	+0.723	<.001	<.001	3	5
CCRCC	SMOC2 →	+1.315	+0.509	<.001	.002	3	5
LSCC	COL15A1 →	+0.991	+0.320	<.001	<.001	3	5
UCEC	PRKG1-AS1 →	+0.542	+0.187	<.001	<.001	3	5
UCEC	CD34 →	+0.560	+0.158	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055015 vs LZTS1 — GBM

Explore this scatter interactively →