Ventricular cardiac muscle cell development

Across TCGA cell cohorts, RNA activity of the Ventricular cardiac muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K8, CDK8, and EXOC3L4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP3K8 grouped by Ventricular cardiac muscle cell development-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MAP3K8 →	-3.307	-0.545	<.001	<.001	3	5
BLOOD_Lymphoma	CDK8 →	+0.980	+0.456	<.001	<.001	3	4
SKIN	EXOC3L4 →	+0.411	+0.239	.002	<.001	3	4
BLOOD_Lymphoma	TIAF1 →	-0.650	-0.470	.006	.003	3	4
LARGE_INTESTINE	PPP6R2 →	-0.467	-0.214	.002	<.001	3	4
BONE	CAT →	-0.793	-0.292	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP3K8 by Ventricular cardiac muscle cell development activity — BLOOD_Lymphoma

Explore this box plot interactively →