Ventricular cardiac muscle cell development

Across TCGA cell cohorts, RNA activity of the Ventricular cardiac muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFOD1, SF3A2, and NFIC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle cell development activity versus OGFOD1 in PANCREAS (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OGFOD1 →	+1.246	+1.636	.001	.002	3	5
LUNG_NSCLC_LUAD	SF3A2 →	+0.618	+1.311	.007	.001	2	6
OVARY	NFIC →	+2.821	+1.596	.002	<.001	2	6
PANCREAS	UBTF →	+0.928	+1.412	.004	.001	3	4
PANCREAS	MLLT1 →	+0.870	+1.485	.002	.003	3	4
PANCREAS	FLOT2 →	+0.679	+1.029	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055015 vs OGFOD1 — PANCREAS

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