Ventricular cardiac muscle tissue morphogenesis

Across TCGA patient cohorts, RNA activity of the Ventricular cardiac muscle tissue morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF17, COMP, and DPYSL3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle tissue morphogenesis activity versus ARHGEF17 in UCEC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGEF17 →	+0.303	+0.056	.004	.008	3	8
BRCA	COMP →	+1.203	+0.041	<.001	<.001	3	7
BRCA	DPYSL3 →	+0.523	+0.033	<.001	<.001	3	7
UCEC	EPB41L2 →	+0.373	+0.050	.001	.002	3	7
UCEC	FKBP7 →	+0.457	+0.081	<.001	<.001	3	7
BRCA	ITIH1 →	+0.467	+0.032	.004	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055010 vs ARHGEF17 — UCEC

Explore this scatter interactively →