Ventricular cardiac muscle tissue morphogenesis

Across TCGA cell cohorts, RNA activity of the Ventricular cardiac muscle tissue morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OVOL1, CRYBG2, and PKP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle tissue morphogenesis activity versus OVOL1 in LUNG_NSCLC_LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OVOL1 →	+1.483	+0.705	<.001	<.001	3	7
URINARY_TRACT	CRYBG2 →	+3.528	+0.598	.002	.009	3	7
LUNG_SCLC	PKP2 →	+1.875	+0.916	.005	.006	2	8
BREAST	IL17RE →	+1.759	+0.601	<.001	.002	3	7
LUNG_NSCLC_LUSC	ALS2CL →	+2.945	+1.836	.002	<.001	3	6
LUNG_NSCLC_LUSC	MEX3B →	-1.868	-1.293	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055010 vs OVOL1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →