Cardiac muscle tissue morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac muscle tissue morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF17, RSU1, and SETD7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle tissue morphogenesis activity versus ARHGEF17 in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGEF17 →	+0.463	+0.052	<.001	<.001	3	8
UCEC	RSU1 →	+0.466	+0.054	.001	<.001	3	7
HNSC	SETD7 →	+0.357	+0.067	<.001	<.001	3	7
BRCA	SPON1 →	+0.820	+0.035	<.001	<.001	3	7
UCEC	SYNPO →	+0.502	+0.040	<.001	.003	3	7
UCEC	AKAP12 →	+0.724	+0.054	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055008 vs ARHGEF17 — UCEC

Explore this scatter interactively →