Cardiac cell development

Across TCGA cell cohorts, RNA activity of the Cardiac cell development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG16L1, STEAP3, and SPEF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATG16L1 grouped by Cardiac cell development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ATG16L1 →	+0.911	+0.247	.006	.006	2	4
OESOPHAGUS	STEAP3 →	+1.058	+0.233	.001	.002	3	3
LUNG_NSCLC_LUSC	SPEF2 →	-1.334	-0.196	.001	.001	3	3
SKIN	IL1R2 →	+0.486	+0.415	.001	.009	3	3
URINARY_TRACT	TBRG4 →	+0.403	+0.273	.008	.009	3	3
URINARY_TRACT	MKNK1 →	+1.047	+0.280	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATG16L1 by Cardiac cell development activity — KIDNEY

Explore this box plot interactively →