Cardiac cell development

Across TCGA cell cohorts, RNA activity of the Cardiac cell development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHL2, ASPH, and RHOC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac cell development activity versus FHL2 in OESOPHAGUS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FHL2 →	+2.181	+0.301	<.001	.008	3	6
OVARY	ASPH →	+1.807	+0.340	.004	.006	3	6
OESOPHAGUS	RHOC →	+0.857	+0.213	.003	.005	3	5
OESOPHAGUS	ARF4 →	+0.875	+0.261	.002	.003	2	6
OESOPHAGUS	ADAM9 →	+1.684	+0.374	.002	<.001	3	5
OVARY	MYBL1 →	+1.406	+0.488	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055006 vs FHL2 — OESOPHAGUS

Explore this scatter interactively →