Cardiac myofibril assembly

Across TCGA patient cohorts, RNA activity of the Cardiac myofibril assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOVA1, SETBP1, and DNASE1L3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac myofibril assembly activity versus NOVA1 in CCRCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NOVA1 →	+0.540	+0.586	.002	.003	3	4
GBM	SETBP1 →	+0.377	+0.322	.004	.004	3	4
UCEC	DNASE1L3 →	+0.458	+0.531	<.001	.003	3	4
UCEC	ZNF366 →	+0.393	+0.454	<.001	.001	3	4
LSCC	RN7SL689P →	-0.396	-1.170	.005	.005	3	4
OV	ELMO1 →	+0.588	+0.912	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055003 vs NOVA1 — CCRCC

Explore this scatter interactively →