Cardiac myofibril assembly

Across TCGA cell cohorts, RNA activity of the Cardiac myofibril assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIEZO2, SCN3A, and CRLF3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac myofibril assembly activity versus PIEZO2 in SOFT_TISSUE (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PIEZO2 →	-4.465	-1.492	<.001	.004	3	3
LUNG_SCLC	SCN3A →	+3.389	+0.916	.002	.008	3	3
LUNG_SCLC	CRLF3 →	-0.887	-1.336	.008	.001	3	3
CNS	BCAS4 →	-1.468	-1.323	<.001	.002	3	3
CNS	SSBP4 →	+0.870	+1.190	.003	.004	3	3
BONE	ATP5IF1 →	+0.689	+1.812	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055003 vs PIEZO2 — SOFT_TISSUE

Explore this scatter interactively →