Striated muscle cell development

Across TCGA cell cohorts, RNA activity of the Striated muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATXN7L2, MYH9, and ITGB1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle cell development activity versus ATXN7L2 in LUNG_NSCLC_LUAD (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ATXN7L2 →	-0.612	-0.077	.005	.001	3	12
BONE	MYH9 →	+1.882	+0.100	<.001	<.001	3	11
BONE	ITGB1 →	+2.478	+0.126	<.001	<.001	3	10
BONE	SERPINE1 →	+4.480	+0.100	.001	<.001	3	10
BONE	PDLIM1 →	+3.866	+0.091	<.001	.007	3	10
BONE	CAVIN1 →	+2.866	+0.092	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055002 vs ATXN7L2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →