Striated muscle cell development

Across TCGA cell cohorts, RNA activity of the Striated muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHL2, NIBAN2, and NCEH1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle cell development activity versus FHL2 in OVARY (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FHL2 →	+2.929	+0.416	<.001	.003	3	7
LUNG_NSCLC_LUSC	NIBAN2 →	+2.247	+0.533	.003	<.001	3	7
LUNG_NSCLC_LUSC	NCEH1 →	+2.392	+0.449	<.001	<.001	3	7
STOMACH	MAP3K5 →	+1.411	+0.387	.005	.002	3	6
STOMACH	ETHE1 →	+1.807	+0.359	.002	.004	3	6
LUNG_NSCLC_LUSC	HPCAL1 →	+2.291	+0.449	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055002 vs FHL2 — OVARY

Explore this scatter interactively →