Muscle cell development

Across TCGA patient cohorts, RNA activity of the Muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALD1, BTN2A3P, and SYPL2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell development activity versus CALD1 in OV (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CALD1 →	+2.187	+0.357	.003	.001	3	2
OV	BTN2A3P →	+1.490	+0.436	.005	.005	3	2
OV	SYPL2 →	+0.266	+0.357	.004	.001	3	2
OV	ZEB1 →	+1.990	+0.357	.009	.001	3	2
OV	ADAM12 →	+2.504	+0.357	.006	.001	3	2
OV	WWC2 →	+1.532	+0.357	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055001 vs CALD1 — OV

Explore this scatter interactively →