Muscle cell development

Across TCGA cell cohorts, RNA activity of the Muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK13, SECISBP2, and MKRN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDK13 grouped by Muscle cell development-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CDK13 →	+1.005	+0.160	.009	.005	2	5
KIDNEY	SECISBP2 →	+0.921	+1.235	.001	.001	3	3
KIDNEY	MKRN1 →	+0.787	+1.497	<.001	<.001	3	3
KIDNEY	EPC2 →	+0.584	+0.982	.003	.004	3	3
KIDNEY	TBRG4 →	+0.617	+1.239	<.001	.002	3	3
KIDNEY	TRIM4 →	+0.847	+1.212	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDK13 by Muscle cell development activity — BLOOD_Myeloma

Explore this box plot interactively →