Muscle cell development

Across TCGA cell cohorts, RNA activity of the Muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF12A, HRH1, and SDC4, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell development activity versus TNFRSF12A in BONE (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TNFRSF12A →	+3.361	+0.097	<.001	<.001	3	12
LUNG_NSCLC_LUSC	HRH1 →	+2.154	+0.115	.001	<.001	3	12
BONE	SDC4 →	+3.210	+0.102	<.001	<.001	3	12
BONE	MYOF →	+3.937	+0.100	<.001	<.001	3	12
LUNG_NSCLC_LUSC	SLC16A3 →	+4.438	+0.132	<.001	<.001	3	11
BONE	ITGB1 →	+2.229	+0.111	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055001 vs TNFRSF12A — BONE

Explore this scatter interactively →