Muscle cell development

Across TCGA cell cohorts, RNA activity of the Muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, CD14, and ETHE1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle cell development activity versus ANXA2 in SKIN (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ANXA2 →	+0.947	+0.223	.001	<.001	3	7
OESOPHAGUS	CD14 →	+1.124	+0.340	.005	<.001	3	7
STOMACH	ETHE1 →	+1.762	+0.386	.002	.002	2	7
OVARY	HPCAL1 →	+1.835	+0.274	<.001	.005	3	6
SKIN	MCU →	+0.838	+0.285	<.001	<.001	3	6
SKIN	CLCF1 →	+1.587	+0.311	.007	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055001 vs ANXA2 — SKIN

Explore this scatter interactively →