Xenobiotic glucuronidation

pathway activity — cross-omics
GO:0052697Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Xenobiotic glucuronidation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ETFB, AKR1B10, and MICAL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCETFB →+0.536+1.336<.001<.00136
LSCCAKR1B10 →+2.575+0.748<.001<.00136
LSCCMICAL2 →-0.387-0.635<.001<.00135
BRCAPDXDC1 →+0.452+0.776<.001.00335
HNSCIDH1 →+0.360+0.883<.001<.00135
LSCCCLPX →+0.430+0.991<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration