Monoacylglycerol catabolic process

Across TCGA patient cohorts, RNA activity of the Monoacylglycerol catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAAH, ABHD6, and GPD1L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoacylglycerol catabolic process activity versus FAAH in GBM (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FAAH →	+0.681	+0.129	<.001	<.001	3	8
UCEC	ABHD6 →	+0.474	+0.134	<.001	.001	3	7
LUAD	GPD1L →	+0.381	+0.063	<.001	<.001	3	7
LUAD	CRYL1 →	+0.354	+0.099	<.001	<.001	3	7
UCEC	CSE1L →	-0.383	-0.133	<.001	<.001	3	7
HNSC	DDX47 →	-0.411	-0.068	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0052651 vs FAAH — GBM

Explore this scatter interactively →