Alditol phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Alditol phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SQOR, PRAC2, and SCN1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alditol phosphate metabolic process activity versus SQOR in GBM (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SQOR →	+0.795	+0.158	<.001	.002	3	4
COAD	PRAC2 →	-0.760	-0.174	.002	<.001	3	4
LUAD	SCN1B →	+0.447	+0.115	.002	.002	3	3
LUAD	GAPDHP31 →	+0.164	+0.102	.001	.002	3	3
LUAD	TXNDC16 →	-0.383	-0.101	<.001	.004	3	3
PDAC	INTS6 →	-0.236	-0.130	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0052646 vs SQOR — GBM

Explore this scatter interactively →