Alditol phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Alditol phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTDSS2, ZNF709, and C19orf73, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTDSS2 grouped by Alditol phosphate metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PTDSS2 →	-0.571	-1.057	.003	.003	3	4
BREAST	ZNF709 →	+0.471	+0.878	.009	.003	3	4
BLOOD_Myeloma	C19orf73 →	+1.173	+1.161	.001	.005	3	4
BONE	ANAPC4 →	+0.579	+1.298	.007	.003	3	4
LUNG_NSCLC_LUSC	INKA1 →	+1.509	+1.497	<.001	.001	3	4
OESOPHAGUS	CAB39L →	-0.910	-1.177	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTDSS2 by Alditol phosphate metabolic process activity — SKIN

Explore this box plot interactively →