Modulation by symbiont of entry into host

Across TCGA patient cohorts, RNA activity of the Modulation by symbiont of entry into host pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM21, TRIM22, and CD74, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by symbiont of entry into host activity versus TRIM21 in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRIM21 →	+0.402	+0.047	<.001	<.001	3	9
LSCC	TRIM22 →	+0.563	+0.073	<.001	<.001	3	9
GBM	CD74 →	+0.829	+0.142	<.001	<.001	3	9
GBM	KCTD12 →	+0.534	+0.091	<.001	<.001	3	8
PDAC	OAS2 →	+0.687	+0.049	.003	<.001	3	8
LSCC	BTK →	+0.430	+0.056	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0052372 vs TRIM21 — OV

Explore this scatter interactively →