Modulation by symbiont of entry into host

Across TCGA cell cohorts, RNA activity of the Modulation by symbiont of entry into host pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM21, PLBD2, and FNDC3B, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by symbiont of entry into host activity versus TRIM21 in KIDNEY (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TRIM21 →	+1.564	+0.183	<.001	<.001	3	17
BLOOD_Leukemia	PLBD2 →	+1.404	+0.088	<.001	<.001	3	16
BLOOD_Lymphoma	FNDC3B →	+2.074	+0.100	<.001	<.001	3	15
BLOOD_Myeloma	SMPD1 →	+1.785	+0.152	<.001	<.001	3	15
BLOOD_Lymphoma	FURIN →	+2.141	+0.098	<.001	<.001	3	15
KIDNEY	ILK →	+0.961	+0.135	<.001	.003	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0052372 vs TRIM21 — KIDNEY

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