Modulation by symbiont of entry into host

Across TCGA cell cohorts, RNA activity of the Modulation by symbiont of entry into host pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, YEATS4, and GPR160, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by symbiont of entry into host activity versus LGALS1 in BONE (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LGALS1 →	+4.725	+0.273	.005	.001	3	13
LUNG_NSCLC_LUSC	YEATS4 →	-1.318	-0.428	.007	.007	3	8
OESOPHAGUS	GPR160 →	-2.189	-0.341	<.001	.002	3	7
BLOOD_Leukemia	PTPN12 →	+1.160	+0.216	.001	<.001	3	7
LUNG_NSCLC_LUAD	FGF2 →	+1.376	+0.214	.007	<.001	3	7
BREAST	KATNAL1 →	+2.118	+0.430	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0052372 vs LGALS1 — BONE

Explore this scatter interactively →