Modulation by symbiont of entry into host

Across TCGA cell cohorts, RNA activity of the Modulation by symbiont of entry into host pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAVIN1, LGALS1, and SUN2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by symbiont of entry into host activity versus CAVIN1 in LUNG_SCLC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CAVIN1 →	+3.552	+0.345	<.001	<.001	3	10
BONE	LGALS1 →	+5.104	+0.258	<.001	<.001	3	10
BREAST	SUN2 →	+1.244	+0.342	.002	<.001	3	9
BREAST	ITGB1 →	+1.202	+0.252	<.001	<.001	3	9
URINARY_TRACT	BSG →	+1.850	+0.327	.007	<.001	3	8
PANCREAS	CAV1 →	+2.548	+0.272	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0052372 vs CAVIN1 — LUNG_SCLC

Explore this scatter interactively →