Regulation of attachment of spindle microtubules to kinetochore

Across TCGA patient cohorts, RNA activity of the Regulation of attachment of spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEIL3, STIL, and HJURP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of attachment of spindle microtubules to kinetochore activity versus NEIL3 in UCEC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NEIL3 →	+0.912	+0.523	<.001	<.001	3	8
UCEC	STIL →	+0.730	+0.527	<.001	<.001	3	8
BRCA	HJURP →	+0.913	+0.498	<.001	<.001	3	8
LSCC	CDC25A →	+0.816	+0.713	<.001	<.001	3	8
LSCC	ZNF367 →	+0.930	+0.666	<.001	<.001	3	8
LSCC	FAM111B →	+0.952	+0.689	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051988 vs NEIL3 — UCEC

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