Regulation of attachment of spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Regulation of attachment of spindle microtubules to kinetochore pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKB, RACGAP1, and BIRC5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AURKB grouped by Regulation of attachment of spindle microtubules to kinetochore-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	AURKB →	-0.376	-0.235	<.001	<.001	2	9
STOMACH	RACGAP1 →	-0.520	-0.218	.003	.009	3	5
LUNG_SCLC	BIRC5 →	-0.413	-0.225	.008	.005	2	6
SOFT_TISSUE	LRRIQ4 →	+0.417	+0.215	.008	.001	3	4
CNS	MOB3C →	+0.147	+0.154	<.001	.006	3	4
CNS	NPR1 →	+0.182	+0.127	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AURKB by Regulation of attachment of spindle microtubules to kinetochore activity — URINARY_TRACT

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