Regulation of attachment of spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Regulation of attachment of spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLDIP2, HARS1, and CRLF3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of attachment of spindle microtubules to kinetochore activity versus POLDIP2 in OESOPHAGUS (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	POLDIP2 →	-0.586	-0.169	.003	.003	3	8
LUNG_NSCLC_LUAD	HARS1 →	-0.443	-0.133	.007	.002	3	6
OESOPHAGUS	CRLF3 →	-0.664	-0.209	.003	.002	3	6
KIDNEY	CDC23 →	-0.763	-0.239	.001	.005	3	5
BREAST	PDSS2 →	-0.959	-0.173	.003	.007	3	5
URINARY_TRACT	GADD45GIP1 →	-0.777	-0.248	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051988 vs POLDIP2 — OESOPHAGUS

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