Positive regulation of attachment of spindle microtubules to kinetochore

Across TCGA patient cohorts, RNA activity of the Positive regulation of attachment of spindle microtubules to kinetochore pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MKI67_S374, IQGAP3_S1424, and RFC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of attachment of spindle microtubules to kinetochore activity versus MKI67_S374 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MKI67_S374 →	+1.104	+0.072	<.001	<.001	3	9
LUAD	IQGAP3_S1424 →	+0.867	+0.098	<.001	<.001	3	9
BRCA	RFC2 →	+0.270	+0.060	.005	.001	3	8
LUAD	RRM2 →	+0.946	+0.142	<.001	<.001	3	8
LUAD	RRM2_S20 →	+1.427	+0.127	<.001	<.001	3	8
LUAD	RRP36_S73 →	+0.762	+0.111	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051987 vs MKI67_S374 — BRCA

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