Positive regulation of attachment of spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Positive regulation of attachment of spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSN, MPDU1, and PGM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MSN grouped by Positive regulation of attachment of spindle microtubules to kinetochore-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MSN →	-5.462	-0.216	.003	.008	3	5
LARGE_INTESTINE	MPDU1 →	-0.871	-0.183	<.001	<.001	3	4
CNS	PGM2 →	-0.824	-0.220	.004	.001	2	5
LARGE_INTESTINE	PIMREG →	-1.360	-0.214	.001	<.001	3	4
LIVER	JUP →	+2.673	+0.244	.002	.006	2	5
URINARY_TRACT	PLEKHG6 →	+5.133	+0.303	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MSN by Positive regulation of attachment of spindle microtubules to kinetochore activity — URINARY_TRACT

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