Negative regulation of chromosome segregation

Across TCGA cell cohorts, RNA activity of the Negative regulation of chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHCTF1, ANKEF1, and RTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AHCTF1 grouped by Negative regulation of chromosome segregation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AHCTF1 →	-0.421	-0.130	.001	<.001	3	5
URINARY_TRACT	ANKEF1 →	+1.939	+0.271	.002	.001	3	4
URINARY_TRACT	RTN1 →	-0.929	-0.235	.007	.001	3	4
URINARY_TRACT	ZCWPW2 →	-0.348	-0.198	<.001	<.001	3	4
LUNG_NSCLC_LUSC	REST →	-0.603	-0.220	<.001	.002	3	4
LUNG_SCLC	ZNF211 →	+0.926	+0.182	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AHCTF1 by Negative regulation of chromosome segregation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →