Negative regulation of chromosome segregation

Across TCGA cell cohorts, RNA activity of the Negative regulation of chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYNLL1, VIM, and MAP3K6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of chromosome segregation activity versus DYNLL1 in CNS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DYNLL1 →	-0.410	-0.856	<.001	<.001	3	4
LUNG_NSCLC_LUAD	VIM →	-4.003	-0.745	<.001	<.001	3	4
BLOOD_Lymphoma	MAP3K6 →	-2.483	-0.623	<.001	.006	3	4
KIDNEY	RBM14 →	+0.732	+1.464	.005	<.001	3	3
CNS	RAB11FIP4 →	+1.323	+0.666	.006	.008	3	3
LUNG_NSCLC_LUAD	HLX →	-0.668	-0.573	.005	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051985 vs DYNLL1 — CNS

Explore this scatter interactively →