Regulation of chromosome segregation

Across TCGA patient cohorts, RNA activity of the Regulation of chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1L2, VHLL, and DIRC3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chromosome segregation activity versus ALDH1L2 in COAD (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ALDH1L2 →	-0.462	-0.899	.005	.002	3	2
COAD	VHLL →	+0.091	+1.205	<.001	<.001	3	2
COAD	DIRC3 →	-0.052	-1.045	.009	.001	3	2
COAD	FGF14-IT1 →	+0.014	+1.045	.009	.007	3	2
COAD	TPBGL →	-0.118	-0.654	.002	.007	3	2
CCRCC	HMOX1 →	-0.606	-0.896	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051983 vs ALDH1L2 — COAD

Explore this scatter interactively →