Regulation of chromosome segregation

Across TCGA patient cohorts, RNA activity of the Regulation of chromosome segregation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCOR1_S260, SMARCA5, and ZNF787, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chromosome segregation activity versus RCOR1_S260 in COAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RCOR1_S260 →	+0.264	+0.937	.001	<.001	3	2
COAD	SMARCA5 →	+0.182	+1.004	<.001	<.001	3	2
CCRCC	ZNF787 →	+0.274	+1.180	.003	<.001	3	2
CCRCC	BUB3 →	+0.179	+1.192	<.001	<.001	3	2
CCRCC	C12orf45 →	+0.423	+0.994	<.001	.006	3	2
CCRCC	CSTF1 →	+0.156	+1.401	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051983 vs RCOR1_S260 — COAD

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