Positive regulation of transmission of nerve impulse

Across TCGA patient cohorts, RNA activity of the Positive regulation of transmission of nerve impulse pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGA2, MOCS2, and ECM1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transmission of nerve impulse activity versus ITGA2 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGA2 →	+0.954	+0.460	<.001	<.001	3	9
BRCA	MOCS2 →	+0.466	+0.142	.001	.006	3	5
PDAC	ECM1 →	+0.533	+0.131	<.001	<.001	3	5
LSCC	RIN2_S366 →	+0.439	+0.118	.001	.007	3	5
PDAC	FRMD6 →	+0.291	+0.101	.006	.004	3	5
LSCC	PHLDA1 →	+0.958	+0.132	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051971 vs ITGA2 — UCEC

Explore this scatter interactively →